Migraines are a constant companion for millions of people worldwide. The debilitating headaches can strike at any moment, leaving sufferers feeling helpless and frustrated. But what if there was a way to stop migraines in their tracks? Enter CGRP inhibitors – a game-changing group of drugs that’s transforming the migraine landscape.
What’s behind the magic?
CGRP (calcitonin gene-related peptide receptor) is a protein that plays a crucial role in sending pain signals during a migraine. Think of it like a key unlocking a lock, triggering the painful experience. CGRP inhibitors work by blocking this key from hitting its lock, preventing the pain signal from being sent.
There are two types of CGRP inhibitors: monoclonal antibodies (mAbs) and receptor antagonists (gepants). mAbs prevent migraines from occurring in the first place, while gepants can both prevent and treat acute migraine attacks. These drugs come in various forms – pills, injections, nose sprays, or IV infusions.
How do CGRP inhibitors work?
CGRP-targeting mAbs are designed to bind specifically to CGRP, preventing it from sending pain signals. Gepants, on the other hand, bind directly to the CGRP receptor, blocking the lock and preventing the key from unlocking the pain response.
Unlike older migraine medications like triptans, which can cause blood vessels to constrict, CGRP inhibitors don’t have this side effect. This makes them a more appealing option for those seeking relief from migraines.
The approved options
Several CGRP inhibitors have received FDA approval for preventing or treating migraines. There are four approved mAbs and four gepants on the market. Each has its own set of side effects, which your doctor can discuss with you in detail.
What to expect when taking CGRP inhibitors
While CGRP inhibitors have revolutionized migraine treatment, they’re not without their own unique challenges. Common side effects include:
* MAb-related side effects: [insert common side effects]
- Gepant-related side effects: [insert common side effects]
As with any medication, it’s essential to talk to your doctor about what to expect and report any changes or concerns.
Important considerations
Before starting treatment with CGRP inhibitors, make sure to discuss the following with your doctor:
* Any pre-existing health conditions
- Other medications, vitamins, or supplements you’re taking
- Pregnancy or breastfeeding plans (some drugs may not be suitable during these times)
- Liver or kidney disease (Nurtec ODT and Ubrelvy may have specific considerations)
By understanding how CGRP inhibitors work and what to expect when taking them, you can take control of your migraine treatment. It’s time to say goodbye to debilitating headaches and hello to a life free from the grip of migraines.
Remember to always consult with your doctor before starting any new medication or treatment plan.
